By the addition of Candida antarctica lipase B into the emulsions, the second-step reaction of enantioselective acylation was achieved with 38 % conversion and 99 % ee. They act not only as asymmetric catalysts for asymmetric transfer hydrogenation from acetophenone to 1-phenylethanol in water with up to 99 % conversion and 93 % ee, but also as an emulsifier to form stable Pickering emulsions. The preparation of particle catalysts is accomplished in just two steps by polymer modifications and 2 coordination, while the benefits of using them for chemoenzymatic synthesis are multifaceted. To address this issue, we present a simple multistep one-pot platform, in which nanoparticle catalysts are prepared to allow chemo- and biocatalytic reactions performed sequentially in water and Pickering emulsions. However, these cascades are often limited due to the incompatibility issue between two distinct catalysts and reactions. Chemoenzymatic cascades are an important tool for advanced synthesis in chemistry.
